Basic action of mitochondria:
The NADPH Oxydase system is found in the mitochondria of our cells. The mitochondria are the energy-producing cells of our body. The mitochondria produce energy (ie ATP) through a complex process called oxidative phosphorylation.
ATP is the molecule that stores energy for the body. The body is constantly producing and utilizing ATP.
There are two cofactors, Vitamins B2 (riboflavin) and B3 (niacin) that are integral to stimulating oxidative phosphorylation and ATP production. Hydrogen peroxide is a byproduct of oxidative phosphorylation. It is this production of hydrogen peroxide that is so critical to the oxidation process of iodine. Hydrogen peroxide and TPO help to oxidize iodide to form iodine.
Regarding the early onset of the illness (autoimmune thyroid disorders):
They seems to be fueled by too much hydrogen peroxide damaging TPO and causing oxidative damage. As the illness progresses, thyroid hormone production can become deranged. Thyroid hormone is integral to stimulating the mitochondria to produce energy or ATP. If the mitochondria are not producing enough energy molecules, fatigue will set it…it becomes necessary to try and stimulate the NADPH oxidase pathway…this pathway is integral to energy production.
How do you increase the production of ATP in the mitochondria? You can provide the correct co-factors in this pathway to increase the production of ATP. Vitamins B2 (riboflavin) and B3 (niacin) are cofactors in the NADPH oxidase pathway and their use can help stimulate the mitochondria to produce more energy as well as provide the thyroid cells with enough H2O2 to properly oxidize iodide.